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Kjell Tore Kalleli's avatar

Onpattro RNAi, adverse reactions from package insert;

(Launch date; August 10, 2018)

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Ingredients of Onpattro may pass into breast milk. Talk to your doctor about stopping breast-feeding

or treatment with Onpattro.

Four serious adverse reactions of atrioventricular (AV) heart block (2.7%) occurred in ONPATTRO-treated patients,

including 3 cases of complete AV block. No serious adverse reactions of AV block were reported in placebo-treated

patients.

Leakage of the drug into the surrounding tissue at the site of infusion, which may cause swelling

or redness

Children and adolescents

Onpattro is not recommended in children and adolescents under 18 years of age.

Insert;

https://www.google.com/url?sa=t&source=web&rct=j&opi=89978449&url=https://www.ema.europa.eu/en/documents/product-information/onpattro-epar-product-information_en.pdf&ved=2ahUKEwjQ99aJz9SBAxUYRvEDHa9MChAQFnoECA0QAQ&usg=AOvVaw1jxhMgvmc5BSRYA4wUTJx1

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Kjell Tore Kalleli's avatar

Genomic Medicine

Strategies to Accelerate Genomic Medicine Development

COVID vaccine development has proven that genomic medicines have the potential for faster drug development. To facilitate new therapeutics, Precision NanoSystems enables access to ionizable lipid mixes through the lipid nanoparticle portfolio, LNP technologies and proven expertise, to establish robust in-house strategies and infrastructure.

Off-the-shelf LNP formulations designed for screening or specific applications, provide an easy entry point for drug development. This allows researchers to save significant time when validating target payloads and delivery systems during preclinical stages. Leveraging optimized lipid mixes also lowers the risk of developing custom LNP formulations, thereby accelerating pre-clinical programs for genomic medicine development.

Genomic medicine is a medical discipline that involves using a person's genomic information as part of their clinical care. Other similar terms include individualized medicine, personalized medicine and precision medicine.

https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.genome.gov/genetics-glossary/Genomic-Medicine&ved=2ahUKEwj2mp_jrOP_AhVMXvEDHQLnAAEQFnoECB4QBQ&usg=AOvVaw2vJVRlFmJWqok4J06mzeR2

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Genomic medicine is an interdisciplinary medical specialty involving the use of genomic information that has rapidly grown since the completion of the Human Genome Project (HGP) more than a decade ago.

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The main difference between genomics and genetics is that genetics scrutinizes the functioning and composition of the single gene where as genomics addresses all genes and their inter relationships in order to identify their combined influence on the growth and development of the organism.

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https://www.google.com/url?sa=t&source=web&rct=j&url=https://www.who.int/news-room/questions-and-answers/item/genomics&ved=2ahUKEwj2mp_jrOP_AhVMXvEDHQLnAAEQFnoECA8QBQ&usg=AOvVaw0fjlZ0etkhPQ_RHUL8P03V

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